Although creation confirms his existence, the created (mankind) turned away from its creater and acts lives contrary to the real aims (the Biblical term for this is “sin”) and therefore has become separated from the source of life.

Romans 1,25

They exchanged the truth about God for a lie, and worshiped and served created things rather than the Creator—who is forever praised.Amen. 

Isaiah 59,2

But your Iniquities have separated you from God; your sins have hidden his face from you, so that he will not hear. 

Romans 3,23

For all have sinned and fall short of the glory of God.

Ephesians 2,1-3

As for you, you were dead in your transgressions and sins, in which you used to live when you followed the ways of this world and of the ruler of the kingdom of the air, the spirit who is now at work in those who are disobedient. All of us also lived among them at one time, gratifying the cravings of our flesh and following its desires and thoughts. Like the rest, we were by nature deserving of wrath.